Currently, the demand on fossil fuels continues increasing even though its use causes several damage to the environment. Biodiesel is a viable alternative to use of conventional diesel; however, biodiesel production is not always efficient and requires to satisfy quality standards. Automatic control improves the quality and efficiency on the production processes. Therefore, to improve productivity and ensure quality of the biodiesel production process in a batch reactor a predictive control strategy was implemented. The control strategy was based in the mathematical model of the reactor. This model describes the dynamics of the reaction and the energy during the production process. In the design of the control strategy, the boiling point restrictions of methanol and the operating range of the actuator were taken into account. The results shown that the products satisfied the requirement of ester content established in the norm EN 14214 and the reaction time was reduced by 42.86\%. In addition, a better performance and lower heating flow consumption, regarding to conventional controller of type proportional integral, was shown by the predictive control system.